Dust polyurethane leather weekly with a microfiber cloth. A thick, woven microfiber cloth should attract dust and remove build up.
Soak up stains immediately with a dry cloth. Polyurethane faux leather is water resistant, but it is also a breathable material. Stains can get stuck in the material's pores.
Make a soap and warm water solution using a mild liquid detergent. Wipe the fabric gently with a non-abrasive sponge, until all the visible dirt is removed.
Remove tough stains by spraying with an alcohol-based all-purpose cleaner, like Formula 409. It will have a better chance of removing stains other than food and dirt.
Rinse the faux leather thoroughly using warm water and a clean, non-soapy sponge. Make sure to get in the crevices of furniture or embossed faux leather so that soap suds or dirt do not get lodged in small cracks or folds.
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